{"id":1504,"date":"2021-01-16T17:40:09","date_gmt":"2021-01-16T15:40:09","guid":{"rendered":"http:\/\/journals.khnu.km.ua\/vestnik\/?p=1504"},"modified":"2021-04-14T14:36:11","modified_gmt":"2021-04-14T11:36:11","slug":"%d0%b1%d1%96%d0%be%d1%81%d1%83%d0%bc%d1%96%d1%81%d0%bd%d1%96-%d0%bd%d0%b5%d1%82%d0%ba%d0%b0%d0%bd%d1%96-%d0%bc%d0%b0%d1%82%d0%b5%d1%80%d1%96%d0%b0%d0%bb%d0%b8-%d0%bd%d0%b0-%d0%be%d1%81%d0%bd%d0%be","status":"publish","type":"post","link":"https:\/\/journals.khnu.km.ua\/vestnik\/?p=1504","title":{"rendered":"\u0411\u0456\u043e\u0441\u0443\u043c\u0456\u0441\u043d\u0456 \u043d\u0435\u0442\u043a\u0430\u043d\u0456 \u043c\u0430\u0442\u0435\u0440\u0456\u0430\u043b\u0438 \u043d\u0430 \u043e\u0441\u043d\u043e\u0432\u0456 \u0445\u0456\u0442\u043e\u0437\u0430\u043d\u0443"},"content":{"rendered":"<p style=\"text-align: center;\">\u0411\u0406\u041e\u0421\u0423\u041c\u0406\u0421\u041d\u0406 \u041d\u0415\u0422\u041a\u0410\u041d\u0406 \u041c\u0410\u0422\u0415\u0420\u0406\u0410\u041b\u0418 \u041d\u0410 \u041e\u0421\u041d\u041e\u0412\u0406 \u0425\u0406\u0422\u041e\u0417\u0410\u041d\u0423<\/p>\n<p style=\"text-align: center;\">BIOCOMPATIBLE NONWOVEN MATERIALS BASED ON CHITOSAN<\/p>\n<p><a href=\"http:\/\/journals.khnu.km.ua\/vestnik\/wp-content\/uploads\/2021\/01\/14-6.pdf\"><img src=\"http:\/\/journals.khnu.km.ua\/vestnik\/wp-content\/uploads\/2021\/01\/pdf.png\" \/><\/a> <strong>\u0421\u0442\u043e\u0440\u0456\u043d\u043a\u0438: 72-76. \u041d\u043e\u043c\u0435\u0440: \u21163, 2019 (273)<\/strong><br \/>\n<strong>\u0410\u0432\u0442\u043e\u0440\u0438:<\/strong><br \/>\n\u041e.\u0412. \u0406\u0429\u0415\u041d\u041a\u041e, \u0412.\u041f. \u041f\u041b\u0410\u0412\u0410\u041d, \u0406.\u041e. \u041b\u042f\u0428\u041e\u041a<br \/>\n\u041a\u0438\u0457\u0432\u0441\u044c\u043a\u0438\u0439 \u043d\u0430\u0446\u0456\u043e\u043d\u0430\u043b\u044c\u043d\u0438\u0439 \u0443\u043d\u0456\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442 \u0442\u0435\u0445\u043d\u043e\u043b\u043e\u0433\u0456\u0439 \u0442\u0430 \u0434\u0438\u0437\u0430\u0439\u043d\u0443<br \/>\nO.V. ISHCHENKO, V.P. PLAVAN, I.O. LIASHOK<br \/>\nKyiv National University of Technologies and Design<br \/>\n<strong>DOI:<\/strong> <a href=\"https:\/\/www.doi.org\/10.31891\/2307-5732-2019-273-3-72-76\">https:\/\/www.doi.org\/10.31891\/2307-5732-2019-273-3-72-76<\/a><br \/>\n<strong>\u0420\u0435\u0446\u0435\u043d\u0437\u0456\u044f\/Peer review :<\/strong> 09.05.2019 \u0440.<br \/>\n<strong>\u041d\u0430\u0434\u0440\u0443\u043a\u043e\u0432\u0430\u043d\u0430\/Printed :<\/strong> 02.06.2019 \u0440.<\/p>\n<p style=\"text-align: center;\"><strong>\u0410\u043d\u043e\u0442\u0430\u0446\u0456\u044f \u043c\u043e\u0432\u043e\u044e \u043e\u0440\u0438\u0433\u0456\u043d\u0430\u043b\u0443<\/strong><\/p>\n<p>\u0423 \u0434\u0430\u043d\u0456\u0439 \u0440\u043e\u0431\u043e\u0442\u0456 \u0434\u043e\u0441\u043b\u0456\u0434\u0436\u0435\u043d\u043e \u043f\u0440\u043e\u0446\u0435\u0441\u0438 \u043e\u0442\u0440\u0438\u043c\u0430\u043d\u043d\u044f \u0431\u0456\u043e\u0441\u0443\u043c\u0456\u0441\u043d\u0438\u0445 \u043d\u0435\u0442\u043a\u0430\u043d\u0438\u0445 \u043c\u0430\u0442\u0435\u0440\u0456\u0430\u043b\u0456\u0432 \u043c\u0435\u0442\u043e\u0434\u043e\u043c \u0435\u043b\u0435\u043a\u0442\u0440\u043e\u0444\u043e\u0440\u043c\u0443\u0432\u0430\u043d\u043d\u044f \u043d\u0430 \u043b\u0430\u0431\u043e\u0440\u0430\u0442\u043e\u0440\u043d\u0456\u0439 \u0443\u0441\u0442\u0430\u043d\u043e\u0432\u0446\u0456 \u043a\u0430\u043f\u0456\u043b\u044f\u0440\u043d\u043e\u0433\u043e \u0442\u0438\u043f\u0443. \u0412\u0438\u0437\u043d\u0430\u0447\u0435\u043d\u0456 \u043e\u0441\u043d\u043e\u0432\u043d\u0456 \u043f\u0430\u0440\u0430\u043c\u0435\u0442\u0440\u0438 \u0435\u043b\u0435\u043a\u0440\u043e\u0444\u043e\u0440\u043c\u0443\u0432\u0430\u043d\u043d\u044f \u0456 \u043c\u043e\u0440\u0444\u043e\u043b\u043e\u0433\u0456\u0447\u043d\u0456 \u0445\u0430\u0440\u0430\u043a\u0442\u0435\u0440\u0438\u0441\u0442\u0438\u043a\u0438 \u043e\u0434\u0435\u0440\u0436\u0430\u043d\u0438\u0445 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\u0434\u043e\u0434\u0430\u0432\u0430\u043d\u043d\u044f\u043c \u0431\u0456\u043e\u0441\u0443\u043c\u0456\u0441\u043d\u043e\u0433\u043e \u043f\u043e\u043b\u0456\u0432\u0456\u043d\u0456\u043b\u043e\u0432\u043e\u0433\u043e \u0441\u043f\u0438\u0440\u0442\u0443 \u0442\u0430 \u043f\u043e\u043b\u0456\u0432\u0456\u043d\u0456\u043b\u0430\u0446\u0435\u0442\u0430\u0442\u0443. \u0412 \u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u0456 \u0434\u043e\u0441\u043b\u0456\u0434\u0436\u0435\u043d\u044c \u043c\u043e\u0440\u0444\u043e\u043b\u043e\u0433\u0456\u0447\u043d\u0438\u0445 \u043e\u0441\u043e\u0431\u043b\u0438\u0432\u043e\u0441\u0442\u0435\u0439 \u043e\u0442\u0440\u0438\u043c\u0430\u043d\u0438\u0445 \u0432\u043e\u043b\u043e\u043a\u043e\u043d \u043c\u0435\u0442\u043e\u0434\u043e\u043c \u0440\u0430\u0441\u0442\u0440\u043e\u0432\u043e\u0457 \u0435\u043b\u0435\u043a\u0442\u0440\u043e\u043d\u043d\u043e\u0457 \u043c\u0456\u043a\u0440\u043e\u0441\u043a\u043e\u043f\u0456\u0457 \u0434\u043e\u0432\u0435\u0434\u0435\u043d\u043e, \u0449\u043e \u043f\u0440\u0438 \u0432\u0438\u0437\u043d\u0430\u0447\u0435\u043d\u0438\u0445 \u043f\u0430\u0440\u0430\u043c\u0435\u0442\u0440\u0430\u0445 \u0435\u043b\u0435\u043a\u0442\u0440\u043e\u0444\u043e\u0440\u043c\u0443\u0432\u0430\u043d\u043d\u044f \u043e\u0442\u0440\u0438\u043c\u0443\u044e\u0442\u044c\u0441\u044f \u0432\u043e\u043b\u043e\u043a\u043d\u0430 \u0437 \u0434\u0456\u0430\u043c\u0435\u0442\u0440\u043e\u043c \u0432\u0456\u0434 0,4 \u0434\u043e 0,9 \u043c\u043a\u043c. \u0412 \u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u0456 \u0432\u0438\u0437\u043d\u0430\u0447\u0435\u043d\u043d\u044f \u0441\u0442\u0430\u0442\u0438\u0441\u0442\u0438\u0447\u043d\u043e\u0433\u043e \u0440\u043e\u0437\u043f\u043e\u0434\u0456\u043b\u0443 \u043f\u043e\u043b\u0456\u043c\u0435\u0440\u043d\u0438\u0445 \u0432\u043e\u043b\u043e\u043a\u043e\u043d \u0443 \u043d\u0435\u0442\u043a\u0430\u043d\u043e\u043c\u0443 \u043c\u0430\u0442\u0435\u0440\u0456\u0430\u043b\u0456 \u0437\u0430 \u0434\u0456\u0430\u043c\u0435\u0442\u0440\u043e\u043c \u0432\u0441\u0442\u0430\u043d\u043e\u0432\u043b\u0435\u043d\u043e, \u0449\u043e 11\u201320 % \u0432\u043e\u043b\u043e\u043a\u043e\u043d \u043c\u0430\u044e\u0442\u044c \u0434\u0456\u0430\u043c\u0435\u0442\u0440 0,4-0,5 \u043c\u043a\u043c, \u044f\u043a\u0456 \u0445\u0430\u0440\u0430\u043a\u0442\u0435\u0440\u0438\u0437\u0443\u044e\u0442\u044c\u0441\u044f \u043d\u0430\u043d\u043e\u0440\u043e\u0437\u043c\u0456\u0440\u0430\u043c\u0438.<br \/>\n<strong>\u041a\u043b\u044e\u0447\u043e\u0432\u0456 \u0441\u043b\u043e\u0432\u0430:<\/strong> \u0435\u043b\u0435\u043a\u0442\u0440\u043e\u0444\u043e\u0440\u043c\u0443\u0432\u0430\u043d\u043d\u044f, \u0431\u0456\u043e\u0441\u0443\u043c\u0456\u0441\u043d\u0456 \u0432\u043e\u043b\u043e\u043a\u043d\u0430, \u043d\u0435\u0442\u043a\u0430\u043d\u0456 \u043c\u0430\u0442\u0435\u0440\u0456\u0430\u043b\u0438, \u0445\u0456\u0442\u043e\u0437\u0430\u043d.<\/p>\n<p style=\"text-align: center;\"><strong>\u0420\u043e\u0437\u0448\u0438\u0440\u0435\u043d\u0430 \u0430\u043d\u043e\u0442\u0430\u0446\u0456\u044f \u0430\u043d\u0433\u043b\u0456\u0439\u0441\u044c\u043a\u043e\u044e \u043c\u043e\u0432\u043e\u044e<\/strong><\/p>\n<p>The object of research is biocompatible composite nanofiber nonwoven materials with antiseptic properties, obtained by the electrospinning method. One of the most problematic places is the creation of a nonwoven biocompatible composite material with antiseptic and bac-tericidal properties; it has not previously been converted into fibers by electrospinning through high energy and financial costs. The composition of biocompatible polymers is used: chitosan, polyvinyl acetate (PVAC) and polyvinyl alcohol (PVA). The electro-spinning method on the capillary type laboratory installation with a \u00abbottom-up\u00bb solution is proposed for the production of nonwoven polymeric materials. Biocompatible composite nonwovens with antiseptic properties are obtained. This is due to the fact that the proposed method of electrospinning allows to obtain nonwoven materials with a certain statistical distribution of fibers, has several features when a solution of chitosan in lactic, formic, \u0430cetic acids and antiseptic\u00a0 drugs\u00a0 is introduced into the composition. The parameters of electrospinning have been determined and morphological characteristics of the received chitosan-based fibers with addition of antiseptic drugs have been studied. The optimum voltage of the electric field of 30 kV and the distance between the electrodes 9-11 cm are found for obtaining chitosan fibers with the addition of biocompatible polyvinyl alcohol and polyvinyl acetate. As a result of investigations of morphological features for the obtained fibers by raster electron microscopy, it has been proved that fibers with a diameter of 0.4 to 0.9 \u03bcm can be obtained at the determined electrospinning parameters. The distribution of polymer fibers in a nonwoven material by diameter shows that 11-20% of fibers have a diameter of 0.4 &#8211; 0.5 \u03bcm, which are characterized by nanosizes. A part of the fibers obtained in the laboratory installation of capillary electrospinning correspond to the area of nano-dimensions, which opens up prospects for obtaining biocompatible nanofibers with antiseptic and fungicidal properties. Therefore, the production of polymer biocompatible nonwovens by electrospinning can be used to create therapeutic systems.<br \/>\n<strong>Key words:<\/strong> electrospinning, biocompatible fibers, nonwoven materials, chitosan.<\/p>\n<p style=\"text-align: center;\"><strong>References<\/strong><\/p>\n<ol>\n<li>Davtyan L.L. Polimernye materialy i medicinskie plenki \/ L.L. Davtyan \/\/ L\u0456ki Ukra\u0457ni. \u2013 2000. \u2013 \u2116 7-8. \u2013 S. 52\u201355.<\/li>\n<li>Davtian L.L. Tekhnolohichna liniia vyrobnytstva likarskykh plivok \/ L.L. Davtian, A.L. Davtian \/\/ Farm. Zh. \u2013 2003. \u2013 \u2116 3. \u2013 S. 88\u201392.<\/li>\n<li>Liao S. Electrospun nanofibers: Work for medicine? \/ S. Liao, C.K. Chan, S. Ramakrishna \/\/ Front. Mater. Sci. China. \u2013 2010. \u2013 Vol. 4, \u2116 1. \u2013 P. 29\u201333.<\/li>\n<li>Prokopchuk N. R. Elektroformovanie nanovolokon iz rastvora hitozana (obzor) \/ N. R. Prokopchuk, Zh. S. Shashok, D. V. Prischepenko, V. D. Melamed \/\/ Polimernye materialy i tehnologii \u2013 2015. \u2013 T. 1, \u2116 2. \u2013 C. 36\u201356.<\/li>\n<li>Aragwal S. Use of electrospinning technique for biomedical applications \/ S. Aragwal, J.H. Wendorff, A. Greiner \/\/ Polymer. \u2013 2008. \u2013 Vol. 49. \u2013 P. 5603\u20135621.<\/li>\n<li>Chitosan chemistry and pharmaceutical perspectives \/ M. N. Kumar, R. A. Muzzarelli, C. Muzzarelli [et al.] \/\/ Chem. Rev. \u2013 2004. \u2013 Vol. 104, N 12. \u2013 P. 6017\u20136084.<\/li>\n<li>Gal&#8217;brayh L.S. Hitin i hitozan: stroenie, svoystva, primenenie \/ L.S. Gal&#8217;brayh \/\/ Sorovskiy obrazovatel&#8217;nyy zhurnal. \u2013 2001. \u2013 T. 7, \u2116 1. \u2013 S. 51\u201356.<\/li>\n<li>Prokopchuk N. R. Elektroformovanie nanovolokon iz rastvora hitozana (obzor) \/ N. R. Prokopchuk, Zh. S. Shashok, D. V. Prischepenko, V. D. Melamed \/\/ Polimernye materialy i tehnologii. \u2013 2015. \u2013 T. 1. \u2116 2. \u2013 S. 36\u201356.<\/li>\n<li>Koliada M. Characterisation of electrospun fibers made of PVA or PVAc and collagen derivative \/ M. Koliada, O. Ishchenko, V. Plavan and V. Bessarabov \/\/ Vlakna a textile. \u2013 2018. \u2013 Vol. 25 (2). \u2013 P. 48\u201352.<\/li>\n<li>Ishchenko O. Producing of nonwoven materials by electrospinning of biocompatible polymers with chitosan addition \/ O. Ishchenko, V. Plavan, I. Resnytskyi, I. Liashok \/\/ Tekhnolohycheskyi audyt y rezerv\u044b proyzvodstva. \u2013 2018. \u2013 \u2116 5\/3(43). \u2013 C. 4\u20137.<\/li>\n<li>Yu J.H. The Role of Elasticity in the Formation of Electrospun Fibers \/ J.H. Yu, S.V. Fridrikh, G.C. Rutledge \/\/ Polymer. \u2013 2006. \u2013 V. 47 (13). \u2013 P. 4789\u20134797.<\/li>\n<li>Ohkawa K. Chitosan Nanofiber \/ K. Ohkawa, K.-I. to Mina \/\/ Biomacromolecules. \u2013 2006. \u2013 V. 7. \u2013 P. 3291\u20133294.<\/li>\n<li>Duan B. Electrospinning of chitosan solutions in acetic acid with poly(ethylene oxide) \/ B. Duan, C. Don \/\/ J. Biomater Sci. Polymer Ed. \u2013 2004. \u2013 V. 15 (6). \u2013 P. 797\u2013811.<\/li>\n<li>Lou C-W. Preparation of polyethylene oxide\/chitosan fiber membranes by electrospinning and the evaluation of biocompatibility \/ C-W. Lou, J-H. Lin \/\/ Text. Res. J. \u2013 2008. \u2013 V. 78 (3). \u2013 P. 254\u2013257.<\/li>\n<li>Zhang Y. Preparation of electrospun chitosan\/poly (vinyl alcohol) membranes \/ Zhang Y., Huang X. e.a. \/ Colloid. Polymer Sci. \u2013 2007. \u2013 V. 285 (8). \u2013 P. 855\u2013863.<\/li>\n<li>Isaiev S.H. Syntez ta antymikrobna aktyvnist pokhidnykh 5-nitro-9- N &#8211; R -akrydynu \/ S. H. Isaiev, O. O. Pavlii, O. O. Ohirenko, A. O. Tkach, N. O. Volkova \/\/ Visnyk farmatsii. \u2013 2000. \u2013 \u2116 2. \u2013 S. 7\u201310.<\/li>\n<li>Ishchenko O.V. Vykorystannia pokhidnykh akrydynu dlia stvorennia novykh biolohichno aktyvnykh materialiv \/ O.P. Sumska, N.V. Panchenko, O.V. Ishchenko \/\/ Syntez i analiz biolohichno\u00a0 aktyvnykh\u00a0 rechovyn i likarskykh\u00a0 substantsii : tezy dopovidei Vseukr. nauk.-prakt. konf. z mizhnar. uchastiu, prysviachenoi 80-richchiu z dnia narodzhennia doktora farmatsevtychnykh nauk, profesora O. M. Haidukevycha (12-13 kvitnia 2018 r.). \u2013 Kh. : NFaU, 2018. \u2013 S. 188\u2013189.<\/li>\n<li>Perez J., Pascau J. Image processing with ImageJ, Packt Publishing Ltd. 2013. 140 p.<\/li>\n<li>Hill, T., Lewicki, P. Statistics: methods and applications\u202f: a comprehensive reference for science, industry, and data mining, StatSoft Inc., 2006. 832 p.<\/li>\n<li>Tehnologiya Nanospider&#x2122; [Elektronnyy resurs] \/\/ Elmarko. \u2013 Rezhim dostupa : http:\/\/www.elmarco.com\/electrospinning\/key-features-of-nanofibers\/<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>\u0411\u0406\u041e\u0421\u0423\u041c\u0406\u0421\u041d\u0406 \u041d\u0415\u0422\u041a\u0410\u041d\u0406 \u041c\u0410\u0422\u0415\u0420\u0406\u0410\u041b\u0418 \u041d\u0410 \u041e\u0421\u041d\u041e\u0412\u0406 \u0425\u0406\u0422\u041e\u0417\u0410\u041d\u0423 BIOCOMPATIBLE NONWOVEN MATERIALS BASED ON CHITOSAN \u0421\u0442\u043e\u0440\u0456\u043d\u043a\u0438: 72-76. \u041d\u043e\u043c\u0435\u0440: \u21163, 2019 (273) \u0410\u0432\u0442\u043e\u0440\u0438: \u041e.\u0412. \u0406\u0429\u0415\u041d\u041a\u041e, \u0412.\u041f. \u041f\u041b\u0410\u0412\u0410\u041d, \u0406.\u041e. \u041b\u042f\u0428\u041e\u041a \u041a\u0438\u0457\u0432\u0441\u044c\u043a\u0438\u0439 \u043d\u0430\u0446\u0456\u043e\u043d\u0430\u043b\u044c\u043d\u0438\u0439 \u0443\u043d\u0456\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442 \u0442\u0435\u0445\u043d\u043e\u043b\u043e\u0433\u0456\u0439 \u0442\u0430 \u0434\u0438\u0437\u0430\u0439\u043d\u0443 O.V. ISHCHENKO, V.P. PLAVAN, I.O. LIASHOK Kyiv National University of Technologies and Design DOI: https:\/\/www.doi.org\/10.31891\/2307-5732-2019-273-3-72-76 \u0420\u0435\u0446\u0435\u043d\u0437\u0456\u044f\/Peer review : 09.05.2019 \u0440. \u041d\u0430\u0434\u0440\u0443\u043a\u043e\u0432\u0430\u043d\u0430\/Printed : 02.06.2019 \u0440. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[20],"tags":[],"_links":{"self":[{"href":"https:\/\/journals.khnu.km.ua\/vestnik\/index.php?rest_route=\/wp\/v2\/posts\/1504"}],"collection":[{"href":"https:\/\/journals.khnu.km.ua\/vestnik\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/journals.khnu.km.ua\/vestnik\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/journals.khnu.km.ua\/vestnik\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/journals.khnu.km.ua\/vestnik\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1504"}],"version-history":[{"count":4,"href":"https:\/\/journals.khnu.km.ua\/vestnik\/index.php?rest_route=\/wp\/v2\/posts\/1504\/revisions"}],"predecessor-version":[{"id":5769,"href":"https:\/\/journals.khnu.km.ua\/vestnik\/index.php?rest_route=\/wp\/v2\/posts\/1504\/revisions\/5769"}],"wp:attachment":[{"href":"https:\/\/journals.khnu.km.ua\/vestnik\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1504"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/journals.khnu.km.ua\/vestnik\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1504"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/journals.khnu.km.ua\/vestnik\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1504"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}