{"id":2004,"date":"2021-01-18T18:28:53","date_gmt":"2021-01-18T16:28:53","guid":{"rendered":"http:\/\/journals.khnu.km.ua\/vestnik\/?p=2004"},"modified":"2021-04-14T14:17:53","modified_gmt":"2021-04-14T11:17:53","slug":"%d0%ba%d1%96%d0%b1%d0%b5%d1%80%d1%84%d1%96%d0%b7%d0%b8%d1%87%d0%bd%d1%96-%d0%b1%d1%96%d0%be%d1%81%d0%b5%d0%bd%d1%81%d0%be%d1%80%d0%bd%d1%96-%d1%82%d0%b0-%d1%96%d0%bc%d1%83%d0%bd%d0%be%d1%81%d0%b5","status":"publish","type":"post","link":"https:\/\/journals.khnu.km.ua\/vestnik\/?p=2004","title":{"rendered":"\u041a\u0456\u0431\u0435\u0440\u0444\u0456\u0437\u0438\u0447\u043d\u0456 \u0431\u0456\u043e\u0441\u0435\u043d\u0441\u043e\u0440\u043d\u0456 \u0442\u0430 \u0456\u043c\u0443\u043d\u043e\u0441\u0435\u043d\u0441\u043e\u0440\u043d\u0456 \u0441\u0438\u0441\u0442\u0435\u043c\u0438"},"content":{"rendered":"

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CYBERPHYSIC BIOSENSORS AND IMMUNOSENSORS SYSTEMS<\/p>\n

<\/a> \u0421\u0442\u043e\u0440\u0456\u043d\u043a\u0438: 145-154. \u041d\u043e\u043c\u0435\u0440: \u21161, 2019 (269)<\/strong>
\n\u0410\u0432\u0442\u043e\u0440\u0438:<\/strong>
\n\u0410.\u0421. \u0421\u0412\u0415\u0420\u0421\u0422\u042e\u041a
\n\u0414\u0412\u041d\u0417 \u00ab\u0422\u0435\u0440\u043d\u043e\u043f\u0456\u043b\u044c\u0441\u044c\u043a\u0438\u0439 \u0434\u0435\u0440\u0436\u0430\u0432\u043d\u0438\u0439 \u043c\u0435\u0434\u0438\u0447\u043d\u0438\u0439 \u0443\u043d\u0456\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442 \u0456\u043c\u0435\u043d\u0456 \u0406. \u042f. \u0413\u043e\u0440\u0431\u0430\u0447\u0435\u0432\u0441\u044c\u043a\u043e\u0433\u043e \u041c\u041e\u0417 \u0423\u043a\u0440\u0430\u0457\u043d\u0438\u00bb
\nA.S. Sverstiuk
\nSHEI “I. Ya. Gorbachevsky Ternopil State Medical University of MH of Ukraine”
\nDOI:<\/strong> https:\/\/www.doi.org\/10.31891\/2307-5732-2019-269-1-145-154<\/a>
\n\u0420\u0435\u0446\u0435\u043d\u0437\u0456\u044f\/Peer review :<\/strong> 27.01.2019 \u0440.
\n\u041d\u0430\u0434\u0440\u0443\u043a\u043e\u0432\u0430\u043d\u0430\/Printed :<\/strong> 16.02.2019 \u0440.<\/p>\n

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\n\u041a\u043b\u044e\u0447\u043e\u0432\u0456 \u0441\u043b\u043e\u0432\u0430<\/strong>: \u043a\u0456\u0431\u0435\u0440\u0444\u0456\u0437\u0438\u0447\u043d\u0430 \u0441\u0438\u0441\u0442\u0435\u043c\u0430, \u0431\u0456\u043e\u0441\u0435\u043d\u0441\u043e\u0440\u043d\u0430 \u0441\u0438\u0441\u0442\u0435\u043c\u0430, \u0456\u043c\u0443\u043d\u043e\u0441\u0435\u043d\u0441\u043e\u0440\u043d\u0430 \u0441\u0438\u0441\u0442\u0435\u043c\u0430, \u0432\u0438\u0434\u0438 \u0444\u0456\u0437\u0438\u043a\u043e-\u0445\u0456\u043c\u0456\u0447\u043d\u043e\u0433\u043e \u043f\u0435\u0440\u0435\u0442\u0432\u043e\u0440\u0435\u043d\u043d\u044f \u0432\u0438\u043c\u0456\u0440\u044e\u0432\u0430\u043b\u044c\u043d\u043e\u0457 \u0432\u0435\u043b\u0438\u0447\u0438\u043d\u0438.<\/p>\n

\u0420\u043e\u0437\u0448\u0438\u0440\u0435\u043d\u0430 \u0430\u043d\u043e\u0442\u0430\u0446\u0456\u044f \u0430\u043d\u0433\u043b\u0456\u0439\u0441\u044c\u043a\u043e\u044e \u043c\u043e\u0432\u043e\u044e<\/strong><\/p>\n

The main approaches underlying the development of cyberphysical biosensory and immunosensory systems are considered. The classification of developed systems based on sensitive elements and using different modes of physic-chemical transformation of the measuring quantity is carried out. The basic technical characteristics of cyberphysical biosensory and immunosensory systems are considered. The technical strategies used to develop biosensor and immunosensory systems based on the identification of biomarkers with and without the use of labels are presented. The paper deals with electrochemical, optical, silicon oxide based on nanomaterials, genetically encoded and cellular, cyberphysical biosensory and immunosensory systems developed using synthetic biology and genetic engineering. The biosensor and immunosensory systems are generalized, in relation to the principles of their work and areas of application. An approach to the development of cyberphysical biosensory and immunosensory systems using discrete population dynamics is considered, which is combined with the dynamic logic used for discrete events. A class of latency lattice differential equations that simulates the interaction of antigens and antibodies in immunopixels is used. The spatial operator simulates the interaction of the type of diffusion between the immunopips. The result of numerical simulation of the electronics signal from the converter of the cyberphysical immunosensory system, which characterizes the number of fluorescing pixels, is presented. The considered immunosensors are presented as a two-dimensional array of immunopicles. To take into account the continuous dynamics of the immunological response, each immunopixel is considered as a cyberphysical immunosensory system. The result of numerical modelling of the cyberphysical immunosensory system, in which there is a chaotic wave of fluorescing pixels, is presented.
\nKey words:<\/strong> cyberphysical system, biosensor system, immunosensory system, types of physic-chemical transformation of the measuring quantity.<\/p>\n

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    \u041a\u0406\u0411\u0415\u0420\u0424\u0406\u0417\u0418\u0427\u041d\u0406 \u0411\u0406\u041e\u0421\u0415\u041d\u0421\u041e\u0420\u041d\u0406 \u0422\u0410 \u0406\u041c\u0423\u041d\u041e\u0421\u0415\u041d\u0421\u041e\u0420\u041d\u0406 \u0421\u0418\u0421\u0422\u0415\u041c\u0418 CYBERPHYSIC BIOSENSORS AND IMMUNOSENSORS SYSTEMS \u0421\u0442\u043e\u0440\u0456\u043d\u043a\u0438: 145-154. \u041d\u043e\u043c\u0435\u0440: \u21161, 2019 (269) \u0410\u0432\u0442\u043e\u0440\u0438: \u0410.\u0421. \u0421\u0412\u0415\u0420\u0421\u0422\u042e\u041a \u0414\u0412\u041d\u0417 \u00ab\u0422\u0435\u0440\u043d\u043e\u043f\u0456\u043b\u044c\u0441\u044c\u043a\u0438\u0439 \u0434\u0435\u0440\u0436\u0430\u0432\u043d\u0438\u0439 \u043c\u0435\u0434\u0438\u0447\u043d\u0438\u0439 \u0443\u043d\u0456\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442 \u0456\u043c\u0435\u043d\u0456 \u0406. \u042f. \u0413\u043e\u0440\u0431\u0430\u0447\u0435\u0432\u0441\u044c\u043a\u043e\u0433\u043e \u041c\u041e\u0417 \u0423\u043a\u0440\u0430\u0457\u043d\u0438\u00bb A.S. Sverstiuk SHEI “I. Ya. Gorbachevsky Ternopil State Medical University of MH of Ukraine” DOI: https:\/\/www.doi.org\/10.31891\/2307-5732-2019-269-1-145-154 \u0420\u0435\u0446\u0435\u043d\u0437\u0456\u044f\/Peer review : 27.01.2019 \u0440. \u041d\u0430\u0434\u0440\u0443\u043a\u043e\u0432\u0430\u043d\u0430\/Printed : 16.02.2019 \u0440. […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[21],"tags":[],"_links":{"self":[{"href":"https:\/\/journals.khnu.km.ua\/vestnik\/index.php?rest_route=\/wp\/v2\/posts\/2004"}],"collection":[{"href":"https:\/\/journals.khnu.km.ua\/vestnik\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/journals.khnu.km.ua\/vestnik\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/journals.khnu.km.ua\/vestnik\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/journals.khnu.km.ua\/vestnik\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2004"}],"version-history":[{"count":4,"href":"https:\/\/journals.khnu.km.ua\/vestnik\/index.php?rest_route=\/wp\/v2\/posts\/2004\/revisions"}],"predecessor-version":[{"id":5743,"href":"https:\/\/journals.khnu.km.ua\/vestnik\/index.php?rest_route=\/wp\/v2\/posts\/2004\/revisions\/5743"}],"wp:attachment":[{"href":"https:\/\/journals.khnu.km.ua\/vestnik\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2004"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/journals.khnu.km.ua\/vestnik\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2004"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/journals.khnu.km.ua\/vestnik\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2004"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}