{"id":2139,"date":"2021-01-18T19:08:29","date_gmt":"2021-01-18T17:08:29","guid":{"rendered":"http:\/\/journals.khnu.km.ua\/vestnik\/?p=2139"},"modified":"2021-03-30T12:54:41","modified_gmt":"2021-03-30T09:54:41","slug":"%d1%83%d0%b4%d0%be%d1%81%d0%ba%d0%be%d0%bd%d0%b0%d0%bb%d0%b5%d0%bd%d0%bd%d1%8f-%d0%bb%d0%b0%d0%b1%d0%be%d1%80%d0%b0%d1%82%d0%be%d1%80%d0%bd%d0%be%d0%b3%d0%be-%d0%bc%d0%b5%d1%82%d0%be%d0%b4%d1%83","status":"publish","type":"post","link":"https:\/\/journals.khnu.km.ua\/vestnik\/?p=2139","title":{"rendered":"\u0423\u0434\u043e\u0441\u043a\u043e\u043d\u0430\u043b\u0435\u043d\u043d\u044f \u043b\u0430\u0431\u043e\u0440\u0430\u0442\u043e\u0440\u043d\u043e\u0433\u043e \u043c\u0435\u0442\u043e\u0434\u0443 \u043e\u043a\u0438\u0441\u043d\u0435\u043d\u043d\u044f \u0431\u0435\u043d\u0437\u0438\u043b\u043e\u0432\u0438\u0445 \u0441\u043f\u0438\u0440\u0442\u0456\u0432 \u0434\u043e \u0432\u0456\u0434\u043f\u043e\u0432\u0456\u0434\u043d\u0438\u0445 \u0430\u043b\u044c\u0434\u0435\u0433\u0456\u0434\u0456\u0432"},"content":{"rendered":"

\u0423\u0414\u041e\u0421\u041a\u041e\u041d\u0410\u041b\u0415\u041d\u041d\u042f \u041b\u0410\u0411\u041e\u0420\u0410\u0422\u041e\u0420\u041d\u041e\u0413\u041e \u041c\u0415\u0422\u041e\u0414\u0423 \u041e\u041a\u0418\u0421\u041d\u0415\u041d\u041d\u042f \u0411\u0415\u041d\u0417\u0418\u041b\u041e\u0412\u0418\u0425 \u0421\u041f\u0418\u0420\u0422\u0406\u0412 \u0414\u041e \u0412\u0406\u0414\u041f\u041e\u0412\u0406\u0414\u041d\u0418\u0425 \u0410\u041b\u042c\u0414\u0415\u0413\u0406\u0414\u0406\u0412<\/p>\n

IMPROVEMENT OF THE LABORATORY METHOD of BENZYL ALCOHOLS OXIDATION TO THE RELEVANT ALDEHYDES<\/p>\n

<\/a> \u0421\u0442\u043e\u0440\u0456\u043d\u043a\u0438: 91-93. \u041d\u043e\u043c\u0435\u0440: \u21162, 2019 (271)<\/strong>
\n\u0410\u0432\u0442\u043e\u0440\u0438:<\/strong>
\n\u041a. \u0406. \u041f\u0415\u0422\u041a\u041e
\n\u0406\u043d\u0441\u0442\u0438\u0442\u0443\u0442 \u043e\u0440\u0433\u0430\u043d\u0456\u0447\u043d\u043e\u0457 \u0445\u0456\u043c\u0456\u0457 \u041d\u0410\u041d \u0423\u043a\u0440\u0430\u0457\u043d\u0438, \u043c. \u041a\u0438\u0457\u0432
\n\u0410. \u041f. \u0421\u0422\u0420\u041e\u041a\u0410\u041d\u042c, \u0413. \u0406. \u0425\u0410\u0420\u0418\u0422\u041e\u041d\u0415\u041d\u041a\u041e
\n\u041a\u0438\u0457\u0432\u0441\u044c\u043a\u0438\u0439 \u043d\u0430\u0446\u0456\u043e\u043d\u0430\u043b\u044c\u043d\u0438\u0439 \u0443\u043d\u0456\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442 \u0442\u0435\u0445\u043d\u043e\u043b\u043e\u0433\u0456\u0439 \u0442\u0430 \u0434\u0438\u0437\u0430\u0439\u043d\u0443
\n\u041a. \u0406. PETKO
\nInstitute of Organic Chemistry NAS of Ukraine, Kyiv
\n\u0410. P. STROKAN, A. I. KHARYTONENKO
\nKyiv National University of Technologies and Design
\nDOI:<\/strong> https:\/\/www.doi.org\/10.31891\/2307-5732-2019-271-2-91-93<\/a>
\n\u0420\u0435\u0446\u0435\u043d\u0437\u0456\u044f\/Peer review :<\/strong> 04.03.2019 \u0440.
\n\u041d\u0430\u0434\u0440\u0443\u043a\u043e\u0432\u0430\u043d\u0430\/Printed :<\/strong> 10.04.2019 \u0440.<\/p>\n

\u0410\u043d\u043e\u0442\u0430\u0446\u0456\u044f \u043c\u043e\u0432\u043e\u044e \u043e\u0440\u0438\u0433\u0456\u043d\u0430\u043b\u0443<\/strong><\/p>\n

\u0414\u043e\u0441\u043b\u0456\u0434\u0436\u0435\u043d\u043e \u0440\u0435\u0430\u043a\u0446\u0456\u044e \u043e\u043a\u0438\u0441\u043d\u0435\u043d\u043d\u044f \u043f-\u043c\u0435\u0442\u0438\u043b\u0431\u0435\u043d\u0437\u0438\u043b\u043e\u0432\u043e\u0433\u043e \u0442\u0430 \u043f-\u043c\u0435\u0442\u043e\u043a\u0441\u0438\u0431\u0435\u043d\u0437\u0438\u043b\u043e\u0432\u043e\u0433\u043e \u0441\u043f\u0438\u0440\u0442\u0456\u0432 \u0434\u043e \u0432\u0456\u0434\u043f\u043e\u0432\u0456\u0434\u043d\u0438\u0445 \u0430\u043b\u044c\u0434\u0435\u0433\u0456\u0434\u0456\u0432 \u0434\u0456\u0454\u044e \u0440\u043e\u0437\u0432\u0435\u0434\u0435\u043d\u043e\u0457 \u0430\u0437\u043e\u0442\u043d\u043e\u0457 \u043a\u0438\u0441\u043b\u043e\u0442\u0438. \u041f\u043e\u043a\u0430\u0437\u0430\u043d\u043e, \u0449\u043e \u0437\u043d\u0438\u0436\u0435\u043d\u043d\u044f \u043a\u043e\u043d\u0446\u0435\u043d\u0442\u0440\u0430\u0446\u0456\u0457 \u043a\u0438\u0441\u043b\u043e\u0442\u0438 \u0430\u0431\u043e \u0437\u0430\u043c\u0456\u043d\u0430 \u0430\u0437\u043e\u0442\u043d\u043e\u0457 \u043a\u0438\u0441\u043b\u043e\u0442\u0438 \u043d\u0430 \u0430\u0437\u043e\u0442\u0438\u0441\u0442\u0443 \u0434\u0430\u0454 \u043c\u043e\u0436\u043b\u0438\u0432\u0456\u0441\u0442\u044c \u043e\u0442\u0440\u0438\u043c\u0443\u0432\u0430\u0442\u0438 \u0432\u0456\u0434\u043f\u043e\u0432\u0456\u0434\u043d\u0456 \u043f-\u043c\u0435\u0442\u0438\u043b- \u0442\u0430 \u043f-\u043c\u0435\u0442\u043e\u043a\u0441\u0438\u0431\u0435\u043d\u0437\u0430\u043b\u044c\u0434\u0435\u0433\u0456\u0434\u0438 \u0437 \u0431\u0456\u043b\u044c\u0448 \u0432\u0438\u0441\u043e\u043a\u0438\u043c \u0432\u0438\u0445\u043e\u0434\u043e\u043c, \u043f\u043e\u0440\u0456\u0432\u043d\u044f\u043d\u043e \u0437 \u0432\u0456\u0434\u043e\u043c\u043e\u044e \u043c\u0435\u0442\u043e\u0434\u0438\u043a\u043e\u044e [1].
\n\u041a\u043b\u044e\u0447\u043e\u0432\u0456 \u0441\u043b\u043e\u0432\u0430:<\/strong> \u043f-\u043c\u0435\u0442\u0438\u043b\u0431\u0435\u043d\u0437\u0430\u043b\u044c\u0434\u0435\u0433\u0456\u0434,\u00a0 \u043f-\u043c\u0435\u0442\u043e\u043a\u0441\u0438\u0431\u0435\u043d\u0437\u0430\u043b\u044c\u0434\u0435\u0433\u0456\u0434, \u043e\u043a\u0438\u0441\u043d\u0435\u043d\u043d\u044f, \u0431\u0435\u043d\u0437\u0438\u043b\u043e\u0432\u0438\u0439 \u0441\u043f\u0438\u0440\u0442, \u043f-\u043c\u0435\u0442\u0438\u043b\u0431\u0435\u043d\u0437\u0438\u043b\u043e\u0432\u0438\u0439 \u0441\u043f\u0438\u0440\u0442, \u043f-\u043c\u0435\u0442\u043e\u043a\u0441\u0438\u0431\u0435\u043d\u0437\u0438\u043b\u043e\u0432\u0438\u0439 \u0441\u043f\u0438\u0440\u0442.<\/p>\n

\u0420\u043e\u0437\u0448\u0438\u0440\u0435\u043d\u0430 \u0430\u043d\u043e\u0442\u0430\u0446\u0456\u044f \u0430\u043d\u0433\u043b\u0456\u0439\u0441\u044c\u043a\u043e\u044e \u043c\u043e\u0432\u043e\u044e<\/strong><\/p>\n

The reaction of oxidation of p-methylbenzyl, and p-methoxybenzyl alcohols to the corresponding aldehydes with the action of dilute nitric acid was investigated. It has been shown that a decrease in the concentration of nitric acid or the replacement of nitric to nitrous acid technique was devised for obtaining of corresponding p-methyl and p-methoxybenzaldehydes with a higher yield, as compared with the known method [1]. Aromatic aldehydes are widely used in organic synthesis, in particular in the synthesis of pharmaceuticals, perfumes, herbicides, pesticides, and many other chemical compounds with practical applications. Getting and studying the chemical properties of aromatic aldehydes in the laboratory workshop of students-pharmacists is a useful component of practical familiarization with the chemical processes of synthesis of drug compounds. There are quite a few techniques for obtaining aromatic aldehydes in laboratory conditions. The simplest from a formal point of view are the methods of oxidation of the corresponding benzyl alcohols. But the use in practice of such a method, as a rule, leads to low yields of the target products or their complete absence in the reaction medium. The authors of the article optimized the method of oxidation of benzyl alcohols to the corresponding benzaldehydes for cases in which the compounds have electron-donating substituents in the benzene core. The laboratory method for the production of p-methylbenzaldehyde and anisive aldehyde by oxidation of the corresponding benzyl alcohols was proposed.
\nKey words:<\/strong> p-methylbenzaldehyde, p-methoxybenzaldehyde, oxidation, benzyl alcohol, p-methylbenzyl alcohol, p-methoxybenzyl alcohol.<\/p>\n

References<\/strong><\/p>\n

    \n
  1. R. Joshi, K. L. Kataria, S. B. Sawant, J. B. Joshi \/\/ Ind. Eng. Chem. Res.<\/em>, vol. 44, \u2116 2 (2005), <\/em>\u0440.\u00a0325\u2013333.<\/li>\n
  2. L. Barlett, M. E. Blake, J. M. Lones \/\/ Journ. of Amer. Chem. Soc.<\/em>, vol. 127, \u2116 17 (2003), \u0440.\u00a06485\u20136488.<\/li>\n
  3. Khanmohamed, R. Mokhtar, R. Zendehel \/\/ Journ. of Chinese Chem. Soc<\/em>., vol. 75, \u2116 1 (2010), \u0440.\u00a0205\u2013212.<\/li>\n
  4. A. Sousa, J. R. Bernardo, A. C. Fernandes \/\/ Tetr. Lett.,<\/em> vol. 53, \u2116 14 (2012), p. 6205\u20136208.<\/li>\n
  5. F. Demg, Y. Chaol, S. Peng \/\/ Org. Lett.,<\/em> vol. 22, \u2116 11, p. 4888\u20134891.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

    \u0423\u0414\u041e\u0421\u041a\u041e\u041d\u0410\u041b\u0415\u041d\u041d\u042f \u041b\u0410\u0411\u041e\u0420\u0410\u0422\u041e\u0420\u041d\u041e\u0413\u041e \u041c\u0415\u0422\u041e\u0414\u0423 \u041e\u041a\u0418\u0421\u041d\u0415\u041d\u041d\u042f \u0411\u0415\u041d\u0417\u0418\u041b\u041e\u0412\u0418\u0425 \u0421\u041f\u0418\u0420\u0422\u0406\u0412 \u0414\u041e \u0412\u0406\u0414\u041f\u041e\u0412\u0406\u0414\u041d\u0418\u0425 \u0410\u041b\u042c\u0414\u0415\u0413\u0406\u0414\u0406\u0412 IMPROVEMENT OF THE LABORATORY METHOD of BENZYL ALCOHOLS OXIDATION TO THE RELEVANT ALDEHYDES \u0421\u0442\u043e\u0440\u0456\u043d\u043a\u0438: 91-93. \u041d\u043e\u043c\u0435\u0440: \u21162, 2019 (271) \u0410\u0432\u0442\u043e\u0440\u0438: \u041a. \u0406. \u041f\u0415\u0422\u041a\u041e \u0406\u043d\u0441\u0442\u0438\u0442\u0443\u0442 \u043e\u0440\u0433\u0430\u043d\u0456\u0447\u043d\u043e\u0457 \u0445\u0456\u043c\u0456\u0457 \u041d\u0410\u041d \u0423\u043a\u0440\u0430\u0457\u043d\u0438, \u043c. \u041a\u0438\u0457\u0432 \u0410. \u041f. \u0421\u0422\u0420\u041e\u041a\u0410\u041d\u042c, \u0413. \u0406. \u0425\u0410\u0420\u0418\u0422\u041e\u041d\u0415\u041d\u041a\u041e \u041a\u0438\u0457\u0432\u0441\u044c\u043a\u0438\u0439 \u043d\u0430\u0446\u0456\u043e\u043d\u0430\u043b\u044c\u043d\u0438\u0439 \u0443\u043d\u0456\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442 \u0442\u0435\u0445\u043d\u043e\u043b\u043e\u0433\u0456\u0439 \u0442\u0430 \u0434\u0438\u0437\u0430\u0439\u043d\u0443 \u041a. \u0406. PETKO Institute […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[22],"tags":[],"_links":{"self":[{"href":"https:\/\/journals.khnu.km.ua\/vestnik\/index.php?rest_route=\/wp\/v2\/posts\/2139"}],"collection":[{"href":"https:\/\/journals.khnu.km.ua\/vestnik\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/journals.khnu.km.ua\/vestnik\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/journals.khnu.km.ua\/vestnik\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/journals.khnu.km.ua\/vestnik\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2139"}],"version-history":[{"count":3,"href":"https:\/\/journals.khnu.km.ua\/vestnik\/index.php?rest_route=\/wp\/v2\/posts\/2139\/revisions"}],"predecessor-version":[{"id":5288,"href":"https:\/\/journals.khnu.km.ua\/vestnik\/index.php?rest_route=\/wp\/v2\/posts\/2139\/revisions\/5288"}],"wp:attachment":[{"href":"https:\/\/journals.khnu.km.ua\/vestnik\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2139"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/journals.khnu.km.ua\/vestnik\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2139"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/journals.khnu.km.ua\/vestnik\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2139"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}