{"id":9848,"date":"2021-12-14T19:37:11","date_gmt":"2021-12-14T17:37:11","guid":{"rendered":"http:\/\/journals.khnu.km.ua\/vestnik\/?p=9848"},"modified":"2022-01-26T14:16:52","modified_gmt":"2022-01-26T12:16:52","slug":"modelyuvannya-fizyko-himichnyh-ta-biologichnyh-proczesiv-dyferenczialnymy-rivnyannyamy","status":"publish","type":"post","link":"https:\/\/journals.khnu.km.ua\/vestnik\/?p=9848","title":{"rendered":"\u041c\u043e\u0434\u0435\u043b\u044e\u0432\u0430\u043d\u043d\u044f \u0444\u0456\u0437\u0438\u043a\u043e-\u0445\u0456\u043c\u0456\u0447\u043d\u0438\u0445 \u0442\u0430 \u0431\u0456\u043e\u043b\u043e\u0433\u0456\u0447\u043d\u0438\u0445 \u043f\u0440\u043e\u0446\u0435\u0441\u0456\u0432 \u0434\u0438\u0444\u0435\u0440\u0435\u043d\u0446\u0456\u0430\u043b\u044c\u043d\u0438\u043c\u0438 \u0440\u0456\u0432\u043d\u044f\u043d\u043d\u044f\u043c\u0438"},"content":{"rendered":"<p><!--more--><\/p>\n<p style=\"text-align: center;\">\u041c\u041e\u0414\u0415\u041b\u042e\u0412\u0410\u041d\u041d\u042f \u0424\u0406\u0417\u0418\u041a\u041e-\u0425\u0406\u041c\u0406\u0427\u041d\u0418\u0425 \u0422\u0410 \u0411\u0406\u041e\u041b\u041e\u0413\u0406\u0427\u041d\u0418\u0425 \u041f\u0420\u041e\u0426\u0415\u0421\u0406\u0412 \u0414\u0418\u0424\u0415\u0420\u0415\u041d\u0426\u0406\u0410\u041b\u042c\u041d\u0418\u041c\u0418 \u0420\u0406\u0412\u041d\u042f\u041d\u041d\u042f\u041c\u0418<\/p>\n<p style=\"text-align: center;\">MODELING OF PHYSICOCHEMICAL AND BIOLOGICAL PROCESSES DIFFERENTIAL EQUATIONS<\/p>\n<p><strong>\u0421\u0442\u043e\u0440\u0456\u043d\u043a\u0438: <\/strong><strong>177-187<\/strong><strong>. \u041d\u043e\u043c\u0435\u0440: \u21165, 2021 (301)<\/strong> <a href=\"http:\/\/journals.khnu.km.ua\/vestnik\/wp-content\/uploads\/2021\/12\/301-text_2021_5_t-177-187.pdf\"> <img loading=\"lazy\" class=\"size-full wp-image-69 alignnone\" src=\"http:\/\/journals.khnu.km.ua\/vestnik\/wp-content\/uploads\/2021\/01\/pdf.png\" alt=\"\" width=\"76\" height=\"32\" \/><\/a><br \/>\n<strong>\u00a0<\/strong><strong>\u0410\u0432\u0442\u043e\u0440\u0438:<\/strong><br \/>\n\u041c\u0410\u0420\u0426\u0415\u041d\u042e\u041a \u0412.\u041f.<br \/>\n\u0423\u043d\u0456\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442 \u0432 \u0411\u0435\u043b\u044c\u0441\u044c\u043a\u043e \u0411\u044f\u043b\u0430, \u041f\u043e\u043b\u044c\u0449\u0430<br \/>\nORCID ID: 0000-0001-5622-1038<br \/>\ne-mail: vmartsenyuk@ath.bielsko.pl<br \/>\n\u0421\u0412\u0415\u0420\u0421\u0422\u042e\u041a \u0410.\u0421.<br \/>\n\u0422\u0435\u0440\u043d\u043e\u043f\u0456\u043b\u044c\u0441\u044c\u043a\u0438\u0439 \u043d\u0430\u0446\u0456\u043e\u043d\u0430\u043b\u044c\u043d\u0438\u0439 \u043c\u0435\u0434\u0438\u0447\u043d\u0438\u0439 \u0443\u043d\u0456\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442 \u0456\u043c\u0435\u043d\u0456 \u0406.\u042f. \u0413\u043e\u0440\u0431\u0430\u0447\u0435\u0432\u0441\u044c\u043a\u043e\u0433\u043e<br \/>\nORCID ID: 0000-0001-8644-0776<br \/>\ne-mail: sverstyuk@tdmu.edu.ua<br \/>\n\u0411\u0410\u0413\u0420\u0406\u0419-\u0417\u0410\u042f\u0426\u042c \u041e.\u0410.<br \/>\n\u0422\u0435\u0440\u043d\u043e\u043f\u0456\u043b\u044c\u0441\u044c\u043a\u0438\u0439 \u043d\u0430\u0446\u0456\u043e\u043d\u0430\u043b\u044c\u043d\u0438\u0439 \u043c\u0435\u0434\u0438\u0447\u043d\u0438\u0439 \u0443\u043d\u0456\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442 \u0456\u043c\u0435\u043d\u0456 \u0406.\u042f. \u0413\u043e\u0440\u0431\u0430\u0447\u0435\u0432\u0441\u044c\u043a\u043e\u0433\u043e<br \/>\nORCID ID: 0000-0002-5533-3561<br \/>\ne-mail: bagrijzayats@tdmu.edu.ua<br \/>\n\u041f\u0410\u0412\u041b\u0418\u0428\u0418\u041d \u0410.\u0412.<br \/>\n\u0422\u0435\u0440\u043d\u043e\u043f\u0456\u043b\u044c\u0441\u044c\u043a\u0438\u0439 \u043d\u0430\u0446\u0456\u043e\u043d\u0430\u043b\u044c\u043d\u0438\u0439 \u043c\u0435\u0434\u0438\u0447\u043d\u0438\u0439 \u0443\u043d\u0456\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442 \u0456\u043c\u0435\u043d\u0456 \u0406.\u042f. \u0413\u043e\u0440\u0431\u0430\u0447\u0435\u0432\u0441\u044c\u043a\u043e\u0433\u043e<br \/>\nORCID ID: 0000-0002-5506-7582<br \/>\ne-mail: pavlyshynav@tdmu.edu.ua<br \/>\n\u0411\u041e\u0419\u041c\u0418\u0421\u0422\u0420\u0423\u041a \u0406.\u0406.<br \/>\n\u0422\u0435\u0440\u043d\u043e\u043f\u0456\u043b\u044c\u0441\u044c\u043a\u0438\u0439 \u043d\u0430\u0446\u0456\u043e\u043d\u0430\u043b\u044c\u043d\u0438\u0439 \u043c\u0435\u0434\u0438\u0447\u043d\u0438\u0439 \u0443\u043d\u0456\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442 \u0456\u043c\u0435\u043d\u0456 \u0406.\u042f. \u0413\u043e\u0440\u0431\u0430\u0447\u0435\u0432\u0441\u044c\u043a\u043e\u0433\u043e<br \/>\nORCID ID: 0000-0003-3343-3104<br \/>\ne-mail: boymystruk@tdmu.edu.ua<br \/>\nMARTSENYUK VP<br \/>\nUniversity of Bielsko-Bia\u0142a, Poland<br \/>\nSVERSTIUK AS, BAGRIY-ZAYATS OA, PAVLYSHYN AV, BOYMISTRUK II<br \/>\nTernopil National Medical University named after I.Ya. Gorbachevsky<br \/>\n<strong>DOI:<\/strong> <a href=\"https:\/\/www.doi.org\/10.31891\/2307-5732-2021-301-5-177-187\">https:\/\/www.doi.org\/10.31891\/2307-5732-2021-301-5-177-187<\/a><br \/>\n<strong>\u0420\u0435\u0446\u0435\u043d\u0437\u0456\u044f\/Peer review <\/strong>: 08.09.2021\u0440.<br \/>\n<strong>\u041d\u0430\u0434\u0440\u0443\u043a\u043e\u0432\u0430\u043d\u0430\/Printed :<\/strong> 10.10.2021 \u0440.<\/p>\n<p style=\"text-align: center;\"><strong>\u0410\u043d\u043e\u0442\u0430\u0446\u0456\u044f \u043c\u043e\u0432\u043e\u044e \u043e\u0440\u0438\u0433\u0456\u043d\u0430\u043b\u0443<\/strong><\/p>\n<p>\u0423 \u0440\u043e\u0431\u043e\u0442\u0456 \u0440\u043e\u0437\u0433\u043b\u044f\u043d\u0443\u0442\u043e \u043f\u0456\u0434\u0445\u043e\u0434\u0438 \u0434\u043e \u043c\u043e\u0434\u0435\u043b\u044e\u0432\u0430\u043d\u043d\u044f \u0444\u0456\u0437\u0438\u043a\u043e-\u0445\u0456\u043c\u0456\u0447\u043d\u0438\u0445 \u0442\u0430 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\/>\n<strong>\u041a\u043b\u044e\u0447\u043e\u0432\u0456 \u0441\u043b\u043e\u0432\u0430:<\/strong> \u043c\u0430\u0442\u0435\u043c\u0430\u0442\u0438\u0447\u043d\u0435 \u043c\u043e\u0434\u0435\u043b\u044e\u0432\u0430\u043d\u043d\u044f, \u0434\u0438\u0444\u0435\u0440\u0435\u043d\u0446\u0456\u0430\u043b\u044c\u043d\u0456 \u0440\u0456\u0432\u043d\u044f\u043d\u043d\u044f, \u0444\u0456\u0437\u0438\u043a\u043e-\u0445\u0456\u043c\u0456\u0447\u043d\u0456 \u043f\u0440\u043e\u0446\u0435\u0441\u0438.<\/p>\n<p style=\"text-align: center;\"><strong>\u00a0<\/strong><strong>\u0420\u043e\u0437\u0448\u0438\u0440\u0435\u043d\u0430 \u0430\u043d\u043e\u0442\u0430\u0446\u0456\u044f \u0430\u043d\u0433\u043b\u0456\u0439\u0441\u044c\u043a\u043e\u044e \u043c\u043e\u0432\u043e\u044e<\/strong><\/p>\n<p>The approaches to modeling of physicochemical and biological processes of differential equations are explained in the work. The law of radioactive decay, the law of absorption of ionizing radiation by the environment, the law of reproduction of bacteria, the law of dissolution of medicinal substance from a tablet, chemical reactions of the first and second order, mathematical model G.I. Marchuk are resulted, mathematical model of a cyber-physical immunosensory system on a hexagonal lattice using a system of delayed differential equations. The results of mathematical modeling in the form of the results of numerical modeling of the dynamic logic of the cyber-physical immunosensory system are presented. Phase planes, lattice images of the probability of antigen-antibody binding, images of fluorescent pixels, electrical signal from the transducer, which characterizes the number of fluorescent pixels, were obtained. In order to increase the student\u2019s research interest in the study of natural sciences and improve the level of understanding of educational material in the disciplines &#8220;Biophysics with physical methods of analysis&#8221; and &#8220;Higher Mathematics&#8221; it is important to inform students about the latest discoveries in this field of knowledge, modern scientific mathematical and physical schools, because it is largely a motivating factor in the formation of future specialists in medicine, pharmacy, biology. Acquainting students with the current results of their own research allows them to be interested in the process of modeling medical and biological processes using differential equations, motivating them to their own research and development of various biosensor devices.<br \/>\n<strong>Keywords:<\/strong> mathematical modeling, differential equations, physicochemical processes.<\/p>\n<p style=\"text-align: center;\"><strong>References<\/strong><\/p>\n<ol>\n<li>Olar O. I., Mykytiuk O. Yu., Fediv V. I., Ostafiichuk D. I. Metody matematychnoho modeliuvannia yak vazhlyvyi rozdil znan dlia studentiv medychnykh ta farmatsevtychnykh spetsialnostei. Naukova promyslovist Yevropeiskoho kontynentu \u2013 2013 : zb. materialiv IX Mizhnar. nauk.-prakt. konf. \u2013 Praha : Publishing House \u201cEducation and Science\u201d, 2013. \u2013 Rezhym dostupu : https:\/\/core.ac.uk\/download\/pdf\/144954141.pdf.<\/li>\n<li>Filonenko N., Kochenov A., Hnatiuk I. Matematychne modeliuvannia v fizytsi. Naukovi zapysky. \u2013 Vyp. 10. \u2013 Seriia: Problemy metodyky fizyko-matematychnoi i tekhnolohichnoi osvity. Chastyna 2. \u2013 Kirovohrad : RVV KDPU im. V. Vynnychenka, 2016. \u2013 S. 89\u201392.<\/li>\n<li>Martsenyuk V.P., Sverstiuk A.S., Klos-Witkowska A., Horkunenko A.B., Rajba S. Vector of Diagnostic Features in the Form of Decomposition Coefficients of Statistical Estimates Using a Cyclic Random Process Model of Cardiosignal. The 10th IEEE International Conference on Intelligent Data Acquisition and Advanced Computing Systems: Technology and Applications, 18\u201321 September. Metz, 2019. Vol. 1. P. 298\u2013303.<\/li>\n<li>Martseniuk V.P., Sverstiuk A.S. Kompiuterna model kiber-fizychnoi imunosensornoi systemy z vykorystanniam reshitchastykh dyferentsialnykh rivnian iz zapiznenniam na heksahonalnii reshittsi. Naukovyi zhurnal Radioelektronika, informatyka, upravlinnia. 2019. \u2116 2 (49). S. 131\u2013139.<\/li>\n<li>Martsenyuk V., Klos-Witkowska A., Sverstiuk A. Stability investigation of biosensor model based on lattice difference equations. Difference Equations and Discrete Dynamical Systems with Applications. Springer Proceedings in Mathematics and Statistics. 24th ICDEA, Dresden, Germany. 2020. Vol. 312. P. 297\u2013322.<\/li>\n<li>Nakonechnyi O., Martsenyuk V., Sverstiuk A. On Application of Kertesz Method for Exponential Estimation of Neural Network Model with Discrete Delays. In: Zawi\u015blak S., Rysi\u0144ski J. (eds) Engineer of the XXI Century. Mechanisms and Machine Science. Springer, Cham. Projekt interdyscyplinarny projektem XXI wieku. 2020. Vol. 70. P. 165\u2013176.<\/li>\n<li>Martseniuk V.P., Sverstiuk A.S., Dziadevych S.V., Semenets A.V., Palianytsia Yu.B., Sydorov O.P. Matematychna model imunosensoriv dlia monitorynhu navkolyshnoho seredovyshcha. Materialy Pershoho mizhnarodnoho ukraino-nimetskoho sympoziumu Hromadske zdorovia v sotsialnomu i osvitnomu prostori \u2013 vyklyky sohodennia i perspektyvy rozvytku 25\u201326 veresnia 2019 r: Ternopil, 2019. S. 7\u201310.<\/li>\n<li>Martseniuk V.P., Sverstiuk A.S., Dorosh N.V., Semenets A.V., Kuchvara O.M., Palianytsia Yu.B., Kravets N.O., Klymuk N.Ia. Rozrobka matematychnoi modeli kiberfizychnoi biosensornoi systemy dlia fizychnoi reabilitatsii. Materialy Vseukrainskoi naukovo-praktychnoi konferentsii Perspektyvy rozvytku medychnoi ta fizychnoi reabilitatsii na riznykh rivniakh nadannia medychnoi dopomohy, 10\u201311 zhovtnia 2019 r.: Ternopil, 2019. S. 116\u2013119.<\/li>\n<li>Martseniuk V.P., Sverstiuk A.S., Semenets A.V., Andrushchak I.Ie., Kuchvara O.M., Palianytsia Yu.B., Bahrii-Zaiats O.A., Horkunenko A.B. Matematychna model kiberfizychnoi biosensornoi systemy dlia kliniko-laboratornoi diahnostyky. Zbirnyk tez dopovidei Vseukrainskoi naukovo-praktychnoi konferentsii Prykladni aspekty morfolohii eksperymentalnykh i klinichnykh doslidzhen, 10\u201311 zhovtnia 2019 r.: Ternopil, 2019. S. 116\u2013119.<\/li>\n<li>Martsenyuk V. Cyber-physical model of the immunosensor system at the hexagonal lattice with the use of differential equations of the population dynamics \/ A. Sverstiuk \/\/ Innovative Technologies and Scientific Solutions for Industries. \u2013 2019. \u2013 \u2116 1. \u2013 p.75-83.<\/li>\n<li>Sverstiuk A.S. Modeliuvannia kiber-fizychnoi imunosensornoi systemy na priamokutnii reshittsi z vykorystanniam reshitchastykh dyferentsialnykh rivnian iz zapiznenniam \/ A.S. Sverstiuk \/\/ Sensorna elektronika ta mikrosystemni tekhnolohii. \u2013 2019. \u2013 \u2116 2. \u2013 S. 53\u201365.<\/li>\n<li>Sverstiuk A.S. Pro kiber-fizychnu model imunosensornoi systemy na priamokutnii reshittsi z vykorystanniam riznytsevykh rivnian populiatsiinoi dynamiky \/ A.S. Sverstiuk \/\/ Visnyk TNTU. \u2013 2018. \u2013 \u2116 4. \u2013 S. 147-161.<\/li>\n<li>Sverstiuk A.S. Research of Global Attractability of Solutions and Stability of the Immunosensor Model Using Difference Equations on the Hexagonal Lattice \/ A.S. Sverstiuk \/\/ \u201cInnovative biosystems and bioengineering\u201d. \u2013 2019. \u2013 Vol. 3, \u2116 1. \u2013 S. 17-26. doi: 10.20535\/ibb.2019.3.1.157644.<\/li>\n<li>Internet-resurs: https:\/\/www.redblobgames.com\/grids\/hexagons\/.<\/li>\n<li>C. McCluskey, \u201cComplete global stability for an SIR epidemic model with delay \u2014 distributed or discrete,\u201d Nonlinear Analysis: Real World Applications, vol. 11, no. 1, pp. 55\u201359, Feb. 2010. doi: 10.1016\/j.nonrwa.2008.10.014. [Online]. Available: https: \/\/doi.org\/10.1016\/j.nonrwa.2008.10.014.\n<ul>\n<li>Nakonechny and V. Marzeniuk, \u201cUncertainties in medical processes control,\u201d Lecture Notes in Economics and Mathematical Systems, vol. 581, pp. 185\u2013192, 2006, cited By 2. doi: 10 . 1007 \/ 3 &#8211; 540 &#8211; 35262 &#8211; 7 _ 11. [Online]. Available: https : \/ \/ www . scopus . com \/ inward \/ record . uri ? eid = 2 &#8211; s2 . 0 &#8211; 53749093113 &amp; doi = 10 . 1007 % 2f3 &#8211; 540 &#8211; 35262 &#8211; 7_11&amp;partnerID=40&amp;md5=03be7ef103cbbc1e94cacbb471daa03f.\n<ul>\n<li>Prindle, P. Samayoa, I. Razinkov, T. Danino, L. S. Tsimring, and J. Hasty, \u201cA sensing array of radically coupled genetic \u2018biopixels,\u201d Nature, vol. 481, no. 7379, pp. 39\u201344, Dec. 2011. doi: 10 . 1038 \/ nature10722. [Online]. Available: https : \/ \/ doi . org \/ 10 . 1038 \/ nature10722.<\/li>\n<\/ul>\n<\/li>\n<li>Platzer, \u201cDifferential dynamic logic for hybrid systems.,\u201d J. Autom. Reas., vol. 41, no. 2, pp. 143\u2013189, 2008, ISSN: 0168-7433. DOI: 10.1007\/s10817-008-9103-8.<\/li>\n<\/ul>\n<\/li>\n<li>Martsenyuk V. Stability, bifurcation and transition to chaos in a model of immunosensor based on lattice differential equations with delay \/ A. Klos-Witkowska, A. Sverstiuk \/\/ Electronic Journal of Qualitative Theory of Differential Equations: No. 2018(27), r. 1-31. DOI: 10.14232\/ejqtde.2018.1.27.<\/li>\n<li>Hale J. K., Lunel S. M. V. Introduction to functional differential equations. Springer Science\u00a0 &amp;\u00a0 Business\u00a0 Media, 2013, vol. 99.<\/li>\n<li>Suhad Abbas Abid, Ahmed Ahmed Muneer, Israa M.S. Al-Kadmy, Anas A. Sattar, Amany Magdy Beshbishy, Gaber El-Saber Batiha, Helal F. Hetta. Biosensors as a future diagnostic approach for COVID-19, Life Sciences, Volume 273, 2021, 119117, ISSN 0024-3205, <a href=\"https:\/\/doi.org\/10.1016\/j.lfs.2021.119117\">https:\/\/doi.org\/10.1016\/j.lfs.2021.119117<\/a>.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[58],"tags":[],"_links":{"self":[{"href":"https:\/\/journals.khnu.km.ua\/vestnik\/index.php?rest_route=\/wp\/v2\/posts\/9848"}],"collection":[{"href":"https:\/\/journals.khnu.km.ua\/vestnik\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/journals.khnu.km.ua\/vestnik\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/journals.khnu.km.ua\/vestnik\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/journals.khnu.km.ua\/vestnik\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=9848"}],"version-history":[{"count":7,"href":"https:\/\/journals.khnu.km.ua\/vestnik\/index.php?rest_route=\/wp\/v2\/posts\/9848\/revisions"}],"predecessor-version":[{"id":10665,"href":"https:\/\/journals.khnu.km.ua\/vestnik\/index.php?rest_route=\/wp\/v2\/posts\/9848\/revisions\/10665"}],"wp:attachment":[{"href":"https:\/\/journals.khnu.km.ua\/vestnik\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=9848"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/journals.khnu.km.ua\/vestnik\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=9848"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/journals.khnu.km.ua\/vestnik\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=9848"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}