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КІБЕРФІЗИЧНІ БІОСЕНСОРНІ ТА ІМУНОСЕНСОРНІ СИСТЕМИ

CYBERPHYSIC BIOSENSORS AND IMMUNOSENSORS SYSTEMS

Сторінки: 145-154. Номер: №1, 2019 (269)
Автори:
А.С. СВЕРСТЮК
ДВНЗ «Тернопільський державний медичний університет імені І. Я. Горбачевського МОЗ України»
A.S. Sverstiuk
SHEI “I. Ya. Gorbachevsky Ternopil State Medical University of MH of Ukraine”
DOI: https://www.doi.org/10.31891/2307-5732-2019-269-1-145-154
Рецензія/Peer review : 27.01.2019 р.
Надрукована/Printed : 16.02.2019 р.

Анотація мовою оригіналу

Розглянуто основні підходи, які лежать в основі розробки кіберфізичних біосенсорних та імуносенсорних систем. Проведена класифікація розроблюваних систем на основі чутливих елементів та з використанням різних режимів фізико-хімічного перетворення вимірювальної величини. Наведено технічні стратегії, що застосовуються для розробки біосенсорних та імуносенсорних систем, які засновані на виявленні біомаркерів з використанням і без використання міток. Узагальнено біосенсорні та імуносенсорні системи відносно принципів їх роботи та областей застосування. Розглянуто підхід до розробки кіберфізичних біосенсорних та імуносенсорних систем з використанням дискретної популяційної динаміки, яку поєднано з динамічною логікою, що використовується для дискретних подій.
Ключові слова: кіберфізична система, біосенсорна система, імуносенсорна система, види фізико-хімічного перетворення вимірювальної величини.

Розширена анотація англійською мовою

The main approaches underlying the development of cyberphysical biosensory and immunosensory systems are considered. The classification of developed systems based on sensitive elements and using different modes of physic-chemical transformation of the measuring quantity is carried out. The basic technical characteristics of cyberphysical biosensory and immunosensory systems are considered. The technical strategies used to develop biosensor and immunosensory systems based on the identification of biomarkers with and without the use of labels are presented. The paper deals with electrochemical, optical, silicon oxide based on nanomaterials, genetically encoded and cellular, cyberphysical biosensory and immunosensory systems developed using synthetic biology and genetic engineering. The biosensor and immunosensory systems are generalized, in relation to the principles of their work and areas of application. An approach to the development of cyberphysical biosensory and immunosensory systems using discrete population dynamics is considered, which is combined with the dynamic logic used for discrete events. A class of latency lattice differential equations that simulates the interaction of antigens and antibodies in immunopixels is used. The spatial operator simulates the interaction of the type of diffusion between the immunopips. The result of numerical simulation of the electronics signal from the converter of the cyberphysical immunosensory system, which characterizes the number of fluorescing pixels, is presented. The considered immunosensors are presented as a two-dimensional array of immunopicles. To take into account the continuous dynamics of the immunological response, each immunopixel is considered as a cyberphysical immunosensory system. The result of numerical modelling of the cyberphysical immunosensory system, in which there is a chaotic wave of fluorescing pixels, is presented.
Key words: cyberphysical system, biosensor system, immunosensory system, types of physic-chemical transformation of the measuring quantity.

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